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1970 3
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2023 4
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23 results

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Page 1
Ruxolitinib in cytopenic myelofibrosis: Response, toxicity, drug discontinuation, and outcome.
Palandri F, Breccia M, Mazzoni C, Auteri G, Elli EM, Trawinska MM, Polverelli N, Tiribelli M, Benevolo G, Iurlo A, Tieghi A, Heidel FH, Caocci G, Beggiato E, Binotto G, Cavazzini F, Miglino M, Bosi C, Crugnola M, Bocchia M, Martino B, Pugliese N, Biondo M, Venturi M, Scaffidi L, Isidori A, Cattaneo D, Krampera M, Pane F, Cilloni D, Semenzato G, Lemoli RM, Cuneo A, Abruzzese E, Bartoletti D, Paglia S, Vianelli N, Cavo M, Bonifacio M, Palumbo GA. Palandri F, et al. Cancer. 2023 Jun 1;129(11):1704-1713. doi: 10.1002/cncr.34722. Epub 2023 Mar 18. Cancer. 2023. PMID: 36932983 Free article.

In multivariable analysis, high molecular risk mutations (p = .04), intermediate 2/high Dynamic International Prognostic Score System (p < .001) and intermediate 2/high Myelofibrosis Secondary to Polycythemia Vera and Essential Thrombocythemia Prognostic Model (p < .

…
In multivariable analysis, high molecular risk mutations (p = .04), intermediate 2/high Dynamic International Prognostic Score System …
Diagnostic capabilities, clinical features, and longitudinal UBA1 clonal dynamics of a nationwide VEXAS cohort.
Gurnari C, Pascale MR, Vitale A, Diral E, Tomelleri A, Galossi E, Falconi G, Bruno A, Crisafulli F, Frassi M, Cattaneo C, Bertoli D, Bernardi M, Condorelli A, Morsia E, Poloni A, Crisà E, Caravelli D, Triggianese P, Brussino L, Battipaglia G, Bindoli S, Sfriso P, Caroni F, Dragani M, Mallegni F, Pilo F, Firinu D, Curti A, Papayannidis C, Olivieri A, Kordasti S, Albano F, Pane F, Musto P, Bocchia M, Lugli E, Breccia M, Frigeni M, Dagna L, Greco R, Franceschini F, Campochiaro C, Cantarini L, Voso MT. Gurnari C, et al. Am J Hematol. 2024 Feb;99(2):254-262. doi: 10.1002/ajh.27169. Epub 2023 Dec 18. Am J Hematol. 2024. PMID: 38108611
In this nationwide study, we aimed at screenshotting the current diagnostic capabilities and clinical-genomic features of VEXAS, and tracked UBA1 longitudinal clonal dynamics upon different therapeutics, including allogeneic hematopoietic cell transplant. ...MDS was diagno …
In this nationwide study, we aimed at screenshotting the current diagnostic capabilities and clinical-genomic features of VEXAS, and tracked …
When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases.
Boi D, Rubini E, Breccia S, Guarguaglini G, Paiardini A. Boi D, et al. Int J Mol Sci. 2023 Mar 1;24(5):4746. doi: 10.3390/ijms24054746. Int J Mol Sci. 2023. PMID: 36902175 Free PMC article. Review.
Myc transcription factors are key regulators of many cellular processes, with Myc target genes crucially implicated in the management of cell proliferation and stem pluripotency, energy metabolism, protein synthesis, angiogenesis, DNA damage response, and apoptosis. Given the wid …
Myc transcription factors are key regulators of many cellular processes, with Myc target genes crucially implicated in the management of cel …
Emerging concepts for assessing and predicting treatment-free remission in chronic myeloid leukemia patients.
Breccia M, Scalzulli E, Pepe S, Colafigli G, Bisegna ML, Capriata M, Martelli M. Breccia M, et al. Expert Rev Hematol. 2022 Jan;15(1):25-32. doi: 10.1080/17474086.2022.2018296. Epub 2021 Dec 27. Expert Rev Hematol. 2022. PMID: 34894984 Review.
Immunological pathways have been proposed as possible control on successful TFR as also early molecular response dynamics. Appropriate molecular monitoring by RQ-PCR in the TFR phase has been proposed by several international recommendations and digital droplet PCR (ddPCR) …
Immunological pathways have been proposed as possible control on successful TFR as also early molecular response dynamics. Appropriat …
Fault rheology beyond frictional melting.
Lavallée Y, Hirose T, Kendrick JE, Hess KU, Dingwell DB. Lavallée Y, et al. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9276-80. doi: 10.1073/pnas.1413608112. Epub 2015 Jun 29. Proc Natl Acad Sci U S A. 2015. PMID: 26124123 Free PMC article.
We warn of the inadequacy of simple Newtonian viscous analyses and call for the application of more realistic rheological interpretation of pseudotachylyte-bearing fault systems in the evaluation and prediction of their slip dynamics....
We warn of the inadequacy of simple Newtonian viscous analyses and call for the application of more realistic rheological interpretation of …
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
Van de Poël A, Toledo-Sherman L, Breccia P, Cachope R, Bate JR, Angulo-Herrera I, Wishart G, Matthews KL, Martin SL, Peacock M, Barnard A, Cox HC, Jones G, McAllister G, Vater H, Esmieu W, Clissold C, Lamers M, Leonard P, Jarvis RE, Blackaby W, Eznarriaga M, Lazari O, Yates D, Rose M, Jang SW, Muñoz-Sanjuan I, Dominguez C. Van de Poël A, et al. J Med Chem. 2021 Apr 22;64(8):5018-5036. doi: 10.1021/acs.jmedchem.1c00114. Epub 2021 Mar 30. J Med Chem. 2021. PMID: 33783225
Early crustal processes revealed by the ejection site of the oldest martian meteorite.
Lagain A, Bouley S, Zanda B, Miljković K, Rajšić A, Baratoux D, Payré V, Doucet LS, Timms NE, Hewins R, Benedix GK, Malarewic V, Servis K, Bland PA. Lagain A, et al. Nat Commun. 2022 Jul 12;13(1):3782. doi: 10.1038/s41467-022-31444-8. Nat Commun. 2022. PMID: 35821210 Free PMC article.
The formation and differentiation of the crust of Mars in the first tens of millions of years after its accretion can only be deciphered from incredibly limited records. The martian breccia NWA 7034 and its paired stones is one of them. This meteorite contains the oldest m …
The formation and differentiation of the crust of Mars in the first tens of millions of years after its accretion can only be deciphered fro …
Shear behavior of bedding fault material on the basal layer of DGB landslide.
Liang Y, Cui S, Pei X, Zhu L, Wang H, Yang Q. Liang Y, et al. Sci Rep. 2023 Jan 5;13(1):233. doi: 10.1038/s41598-023-27488-5. Sci Rep. 2023. PMID: 36604575 Free PMC article.
Compared with argillaceous materials in the same fault, the mylonitic materials are of higher shear strength and internal friction angle. Both mylonitic materials and breccia materials are strong in liquefying. In saturated undrained cases, shear strength of fault material …
Compared with argillaceous materials in the same fault, the mylonitic materials are of higher shear strength and internal friction angle. Bo …
Submarine metalliferous carbonate mounds in the Cambrian of the Baltoscandian Basin induced by vent networks and water column stratification.
Álvaro JJ, Holmer LE, Shen Y, Popov LE, Ghobadi Pour M, Zhang Z, Zhang Z, Ahlberg P, Bauert H, González-Acebrón L. Álvaro JJ, et al. Sci Rep. 2022 May 19;12(1):8475. doi: 10.1038/s41598-022-12379-y. Sci Rep. 2022. PMID: 35589924 Free PMC article.
Two massive precipitation events of polymetallic ore deposits, encrusted by a mixture of authigenic carbonates, are documented from the Cambrian of the semi-enclosed Baltoscandian Basin. delta(34)S (-9.33 to -2.08) and delta(33)S (-4.75 to -1.06) values from the basal sulphide …
Two massive precipitation events of polymetallic ore deposits, encrusted by a mixture of authigenic carbonates, are documented from the Camb …
Life after ruxolitinib: Reasons for discontinuation, impact of disease phase, and outcomes in 218 patients with myelofibrosis.
Palandri F, Breccia M, Bonifacio M, Polverelli N, Elli EM, Benevolo G, Tiribelli M, Abruzzese E, Iurlo A, Heidel FH, Bergamaschi M, Tieghi A, Crugnola M, Cavazzini F, Binotto G, Isidori A, Sgherza N, Bosi C, Martino B, Latagliata R, Auteri G, Scaffidi L, Griguolo D, Trawinska M, Cattaneo D, Catani L, Krampera M, Lemoli RM, Cuneo A, Semenzato G, Foà R, Di Raimondo F, Bartoletti D, Cavo M, Palumbo GA, Vianelli N. Palandri F, et al. Cancer. 2020 Mar 15;126(6):1243-1252. doi: 10.1002/cncr.32664. Epub 2019 Dec 20. Cancer. 2020. PMID: 31860137 Free article.
Baseline predictors of drug discontinuation were: intermediate-2-risk/high-risk category (Dynamic International Prognostic Score System), a platelet count <100 10(9) per liter, transfusion dependency, and unfavorable karyotype. ...
Baseline predictors of drug discontinuation were: intermediate-2-risk/high-risk category (Dynamic International Prognostic Score Syst …
23 results